A rBCG delivered STING agonist is a better TB vaccine than BCG-WT
![](http://www.bishailab.org/wp-content/uploads/2022/03/BCG-disA-OE.png)
Treg-depletion with re-engineered diphtheria toxin fusion protein (ontak) minimizes vascular leakage and is beneficial in a mouse model
![](http://bishailab.org/Project4_Ontak.png)
Re-engineered BCG over-expressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer
![](http://www.bishailab.org/wp-content/uploads/2022/03/BC-disA-OE.png)
What are the biochemical mediators of cavitation in tuberculosis?
![](http://bishailab.org/Project1_BiochemicalDrivers.png)
FDA approved TNF-response inhibitor, Tofacitinib, is an effective host-directed therapy in a mouse model of TB
![](http://bishailab.org/Project2_Tofa.png)
M.tb secretes a STING agonist, c-di-AMP, which triggers autophagy and increased Type-1 INF responses
![](http://bishailab.org/Project5_STING.png)
Does host enzyme PARP-1 contribute to tuberculosis parthenogenesis and sex differences associated with it.
![](http://bishailab.org/Project6_PARP.png)
Monocyte immunology in the context of TB and BCG
![](http://www.bishailab.org/wp-content/uploads/2022/03/modulation-of-inflammatory-responses-1024x581.jpg)