A rBCG delivered STING agonist is a better TB vaccine than BCG-WT
Treg-depletion with re-engineered diphtheria toxin fusion protein (ontak) minimizes vascular leakage and is beneficial in a mouse model
Re-engineered BCG over-expressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer
What are the biochemical mediators of cavitation in tuberculosis?
FDA approved TNF-response inhibitor, Tofacitinib, is an effective host-directed therapy in a mouse model of TB
M.tb secretes a STING agonist, c-di-AMP, which triggers autophagy and increased Type-1 INF responses